Fine-Tuning CAR T-cell Immunotherapy to Benefit More Kids

Chimeric antigen receptor (CAR) T-cell immunotherapy, which reprograms a child’s white blood cells so they can seek out and destroy cancer cells, is making a difference in children’s lives. Currently, Seattle Children’s has multiple trials open that could benefit children and young adults with relapsed or refractory cancers. In October, Seattle Children’s opened a new […]

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Researchers Discover Areas in the Brain Where Nicotine Could Disrupt Early Brain Development

Researchers at Seattle Children’s Research Institute have discovered that populations of neurons in the brain stem have a previously unrecognized susceptibility to disruption by nicotine during early brain development. Published in the Journal of Comparative Neurology, their findings offer a clue to how nicotine exposure in utero could have a lasting effect on the brain’s […]

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New Contract Will Advance Tuberculosis Research

Seattle Children’s Research Institute is one of three recipients of $30 million in first-year-funding provided by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to establish centers for immunology research to accelerate progress in tuberculosis (TB) vaccine development. The awards provide up to seven years of […]

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Research Reveals How Malaria Parasite Plans Ahead, Preparing Blueprint to Strike in Humans

Within seconds after an infected mosquito bites, the malaria parasite navigates the host skin and blood vessels to invade the liver, where it will stay embedded until thousands of infected cells burst into the bloodstream, launching malaria’s deadly blood-stage infection. Now, for the first time, a team from Seattle Children’s Research Institute describes how malaria […]

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Families Raise Awareness of Rare, Underdiagnosed Lung Disease

Like a typical 13-year-old, Isabelle Zoerb plays volleyball and tap dances. She also regularly uses an inhaler, takes antibiotics to minimize lung inflammation and wears a therapy vest that vibrates to help clear her lungs. A device in her chest provides intravenous medication when needed. This is because Isabelle has primary ciliary dyskinesia (PCD), a […]

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