Dr. Rebecca Gardner, oncologist and lead investigator for Seattle Children’s PLAT-02 trial.
T-cell immunotherapy continues to take center stage as one of the most promising new cancer therapies of our time. After receiving the therapy, which reprograms a person’s own T cells to detect and destroy cancer, 93% of children with acute lymphoblastic leukemia (ALL) who enrolled in Seattle Children’s Pediatric Leukemia Adoptive Therapy (PLAT-02) trial and were unlikely to survive, achieved complete remission. Some are still in remission now more than two years out from the therapy.
This is a message that Dr. Rebecca Gardner, oncologist and lead investigator for the PLAT-02 trial at Seattle Children’s, will be underscoring in her abstract presentations at The American Society of Hematology (ASH) Annual Meeting. However, she will also highlight that there is still work to be done, and will present a possible answer to one of the most challenging puzzles facing researchers in the field: How can we limit the possible side effects of the treatment while retaining the effectiveness of the T cells?
“We are in a pivotal time where we know this therapy works in getting patients who are very sick into remission, but now we’re focusing on how to improve the treatment experience, which includes limiting the possible side effects,” said Gardner. “Our latest results mark an exciting milestone where we have potentially found the key to better controlling the body’s reaction to the T cells while still ensuring efficacy.” Read full post »
Greta Oberhofer’s leukemia is in remission thanks to T-cell immunotherapy developed at Seattle Children’s.
Greta Oberhofer survived a bone marrow transplant for leukemia when she was just 8 months old — but the side effects nearly killed her. Then, six months later, her family’s worst fears came to life.
“My husband put the doctor on speaker phone — he told me Greta relapsed and that her prognosis was bad,” remembers her mother, Maggie Oberhofer. “She had already suffered so much with the chemotherapy and transplant, and we didn’t want to put her through that again. We didn’t know what to do.”
The Oberhofers — who live in Portland — were considering hospice for Greta. Then they heard that Seattle Children’s Dr. Rebecca Gardner was testing a therapy that uses reprogrammed immune cells to attack certain kinds of leukemia.
“Dr. Gardner said not to give up because her therapy was putting kids like Greta in remission, and that the side effects were often a lot easier to tolerate,” Oberhofer says. “We suddenly had a way forward.”
A few months later, the Oberhofers watched Greta’s reprogrammed cells drip into her body. Two weeks after that, her cancer was in remission.
In December of last year, Laura Coffman began to notice that something wasn’t quite right with her 2-year-old son, Hunter. He was leaning to one side and seemed to lose his balance easily. When he became lethargic and started vomiting a few days later on Dec. 28, she knew it was time to see the pediatrician.
After all standard tests came back normal, they were sent to Seattle Children’s for further testing and to find an answer. Unfortunately, it was far worse than anything Coffman could have imagined.
“What I thought was probably just Hunter being a wobbly toddler with a virus turned out to be a brain tumor,” said Coffman. “I will never forget that day. It was the most traumatic six hours of our lives.” Read full post »
Going to summer camp can be perceived as a childhood rite of passage. It’s a place for kids to cut loose and embrace their independence for a few special days. Whether it’s participating in new activities like fishing or archery, or bonding with fellow campers — camp can be a magical place that creates memories that last a lifetime.
Unfortunately for some kids who have medically complex conditions, the idea of going to summer camp doesn’t seem like an option. It can be especially true for children who require a wheelchair or rely on ventilators or feeding tubes to keep their health stable.
It wasn’t an option until a doctor from Seattle Children’s, Dr. Stanley Stamm, came up with a remarkable idea 50 years ago — create a summer camp catered specifically for kids who face serious medical challenges.
Funded exclusively by generous donors so kids can attend for free, the week-long sleepover camp has become a powerful opportunity for campers to connect with peers, as well as former campers turned volunteers who understand what it’s like to live with a chronic illness.
Ever wonder what it’s like to walk in the ‘shoes’, or rather the ‘paw prints’, of a furry friend? In honor of National Dog Day, On the Pulse is featuring one of the incredible canine and human companion pairs that bring joy and comfort to the hospital each week through Seattle Children’s Visiting Dog Program.
Hank, the 5-year-old, 78-pound Old English sheepdog, may seem like an unlikely visitor strolling through the colorful halls of Seattle Children’s, but he’s there for one important reason — to put as many smiles on the faces of young patients as possible.
The shaggy canine with a slow strut makes his rounds visiting patients in different units of the hospital every other Thursday of the month alongside his trusty human companion, Tom Whalen.
During their visits, the “Tom Hanks” duo carry a celebrity-like status, frequently being stopped in the hallways by patients, parents and staff for a quick pet on the head or simple greeting.
From his calm demeanor, soulful stare and wag of the tail each time he encounters someone, it’s clear that Hank, a registered therapy dog who has been visiting the hospital for two years, is skilled in comforting those that he meets.
Katie Belle, now 10 years old, was diagnosed with high-risk neuroblastoma when she was 3.
In August of 2009, when Katie Belle was just 3 1/2 years old, a persistent fever led her to Seattle Children’s Emergency Department where doctors discovered a baseball-sized tumor in her abdomen. She was diagnosed with high-risk neuroblastoma, a cancer that starts in immature nerve cells and develops into tumors. Her chance of survival: 35%.
“I felt like someone stuck a dagger in my stomach,” said Katie’s mother, Jennifer Belle. “I couldn’t breathe. However, I had to put on a brave face for Katie.”
For children with high-risk neuroblastoma, which according to the National Cancer Institute occurs in approximately one out of 100,000 children, Katie’s prognosis was not uncommon. On average, less than 50% of children with this disease live five or more years after diagnosis.
However, a Phase 3 trial performed by the Children’s Oncology Group (COG), and led by Seattle Children’s oncologist Dr. Julie Park, has found that adding a second autologous stem-cell transplant, which is a transplant that uses the patient’s own stem cells, to standard therapy improves outcomes for patients with high-risk neuroblastoma. Read full post »
“As a parent, you never want to hear that your child has cancer,” said Paul Esposito, of Plano, Texas. “It creates an emotion that starts at your feet and takes hold. It’s devastating.”
This was the terrible news Paul and his family received in 2010 when his son, Zane Esposito, was only 7 years old. Zane, now 12, was diagnosed with acute lymphoblastic leukemia (ALL) in June 2010. Zane underwent three grueling years of cancer treatment, including 365 days of chemotherapy, before reaching remission. Two years later, Zane relapsed in January of this year. Their only option: another three years of aggressive chemotherapy.
“I really don’t like chemo, it’s the worst,” said Zane. “My back hurt super bad due to tiny fractures from the chemo. I couldn’t even bend over to tie my shoes. And here I was having to start another three years all over again.”
Not only was the thought of starting over daunting, but Zane faced a major hurdle as he began chemotherapy – his cancer was not responding to the treatment. He had refractory ALL. Zane and his family were desperate for another treatment option.
About 2,000 miles away in Seattle, Wash., they would find that other option. But first, they would learn about it in the most unlikely place: a doughnut shop. Read full post »
Seattle Children’s is proud to announce that this week, Forbes ranked the hospital #10 on its list of “America’s Best Employers” for 2016. Seattle Children’s is also the third highest ranked company in the “Healthcare & Social” category.
Other top-ten companies include Google, Costco Wholesale, SAS and JetBlue Airways.
To create the list, Forbes surveyed more than 30,000 U.S. workers employed by companies with more than 5,000 staff members to determine how likely they were to recommend their employer to someone else, and how they felt about other employers in their industry. To view the full list visit,”America’s Best Employers.”
To better understand what makes Seattle Children’s such a special place to work, watch the video above to hear it firsthand from the faculty and staff members who work here.
Juliana Graceffo, 11, has type 1 diabetes. She must test her blood sugar throughout the day and take carefully calculated doses of insulin.
Children with type 1 diabetes and their families have to do several calculations throughout the day to stay healthy. Did my daughter check her blood sugar before breakfast? Does she need an extra snack because she has gym class? Is there someone at school to help my child check her blood sugar?
Type 1 diabetes is an autoimmune disease that injures the insulin-producing cells in the pancreas and leads to a lifelong requirement of daily insulin injections. It is a considerable burden of care on patients and parents, who effectively never get a rest from the demands of staying healthy and safe.
Madeline Holt is a bubbly, positive 3-year-old who likes to cuddle, listen to music, play with blocks and cars, and, in typical toddler fashion, do what she wants to do when she wants to do it. She is also strong and determined to beat all odds stacked against her.
At age 1, Madeline was diagnosed with Zellweger syndrome, a rare genetic condition that destroys the white matter in her brain. The condition leads to a number of other complications, including seizures, respiratory problems, liver failure and even brain hemorrhages. Most children with Zellweger syndrome do not live past 1.
There’s no treatment for Zellweger syndrome. Instead, caregivers at Seattle Children’s treat Madeline’s symptoms as they occur. Madeline is blind, has very limited mobility now and has a feeding tube. Despite these obstacles, she has mastered 50 different sign language signs.
“You learn to accept the disease for what it is,” said Meagan Holt, Madeline’s mother. “It’s terrible, but for today, she’s here and that’s all we care about.” Read full post »
Seattle Children's complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.