Cancer and Blood Disorders

All Articles in the Category ‘Cancer and Blood Disorders’

Cancer Research at Seattle Children’s Contributes to FDA Approval of CAR T-Cell Immunotherapy Treatment for Adults with Relapsed or Refractory Large B-Cell Lymphoma

The Therapeutics Cell Manufacturing facility at Building Cure translates laboratory discoveries into real-world treatments.

The U.S. Food and Drug Administration on Feb. 5 approved Bristol Myers Squibb’s Breyanzi, a chimeric antigen receptor (CAR) T-cell therapy used to treat adults with certain types of large B-cell lymphoma who have not responded to or who have relapsed after standard treatments.

The approval was supported by research at Seattle Children’s, including the chimeric antigen receptor (CAR) T-cell product, patient product manufacturing for Juno Therapeutics’ TRANSCEND trial, and data from the Pediatric Leukemia Adoptive Therapy (PLAT-02) clinical trial. In the PLAT-02 clinical trial, 93% of patients with relapsed or refractory acute lymphoblastic leukemia achieved initial remission, and about 50% were still in remission one year after therapy. Read full post »

From Patient Family to Employee, Rachel Robinson is Grateful for Seattle Children’s

Rachel Robinson and her family were on a family camping trip when she started to notice something was amiss with her son, Eli. He appeared pale, a hint of green to his complexion, and he was covered in bruises. His identical twin seemed fine, which added to Robinson’s concern.

She called their pediatrician, and they were advised to go to Seattle Children’s as soon as possible. After a blood test, doctors discovered something unimaginable. Eli had cancer.

“It’s something you think is never going to happen to you,” Robinson said. “You wonder if you did something wrong. It was surreal.” Read full post »

Santa Makes Virtual Visits to Seattle Children’s, Music Therapists Sing Carols

This year has been especially difficult for patients and families at Seattle Children’s. Spending time in the hospital is typically not a fun experience, and so for families who have to be inpatient during the holidays, the season may not feel as merry. To help spread joy and brighten up the holidays for children in the hospital, the Child Life team at Seattle Children’s found a new way for Santa to zoom into the hospital this year: they arranged virtual visits, because even during a pandemic, Santa wanted kids in the hospital to know he was thinking about them.

For Melissa Strilecki, 2020 has been more than a difficult year.

“2020 has been the worst year of our lives,” she said.

In May 2020, 3-year-old Hazel came down with what their family thought was a virus. At first, her symptoms didn’t seem insidious. She had a fever and was throwing up. A week later she started complaining of leg pain.

“She was in terrible pain,” Strilecki said. “We couldn’t even pick her up without her crying out.”

They called their pediatrician, and they were advised to take her to Seattle Children’s Emergency Department. At first, they thought her symptoms may have been caused by a bone infection, but after further testing, they received an unimaginable diagnosis: malignant cancer.

“You are told cancer is rare,” Strilecki said. “But it didn’t feel very rare.”

They were devastated. Read full post »

Option To Freeze Ovarian Tissue Gives Young Cancer Patients Hope for Future Fertility

Faye Prekeges’s senior photo, taken one year before her cancer diagnosis. Faye was the first patient at Seattle Children’s to have her ovary removed and frozen to try to preserve her fertility while undergoing treatment for high-risk leukemia.

At 19, Faye Prekeges was not planning for parenthood. She was a freshman at Northeastern University in Boston, Massachusetts. She spent her days thinking about majoring in French and dreaming of working with the United Nations Refugee Agency, not about whether she wanted to be a mother one day.

But an unexpected diagnosis changed all that.

Six weeks into her second semester, Faye began having high fevers and visited the university’s health clinic. Providers suggested she had the flu and would feel better in about a week, but her symptoms quickly grew worse. A few days later, she woke up with a fever of 104 degrees.

Faye thought to herself, “I need to see a doctor now.” She took an Uber to Boston Medical Center’s Emergency Department and tested positive for mononucleosis. They kept her overnight because her white blood cell count was abnormally low.

“Luckily, the woman looking at my slides noticed what she thought were blast cells (primitive, undifferentiated blood cells, often found in the blood of people with acute leukemia) and sent them to the pathologist, who confirmed they were,” Faye said.

She was transferred to Boston Children’s Hospital, where she was diagnosed with high-risk B-cell acute lymphoblastic leukemia.

“I believe everything happens for a reason,” Faye said. “I feel like, this happened to me and my family because we are strong enough to get through it.” Read full post »

Child Life Specialists Help Patients and Families Cope During Uncertain Times

No matter the circumstances outside the walls of the hospital, Seattle Children’s is steadfast in helping every child live the most fulfilling life possible. Although COVID-19 has halted many things in life, health is not one. Compassion and expert care are two infallible aspects that make Seattle Children’s a place families can count on when they need care, and supporting that relentless mission are the incredible health care workers at Seattle Children’s who continue to provide the best, safest care possible for patients and families.

This year, child life specialists at Seattle Children’s have worked tirelessly to try and make the hospital feel like the same inviting and safe place it has always been. They are heroes without capes. Child life specialists help make sure a family’s experience at the hospital is a positive one. As members of the health care team, they work directly with patients and families to help explain a medical diagnosis, create coping plans, teach relaxation techniques, and more.

Walk into the Emergency Department and patients and families will see the bright, welcoming eyes of Riley Coyle. Underneath her mask and face shield, she radiates light. With her warm and inviting personality, she helps patients and families navigate through what can be a traumatic experience. No family hopes to find themselves in the emergency department, but when they do, Coyle is happy to be there with a reassuring hand.

“It’s a huge honor to support our patients and families and be a part of their journey,” Coyle said. “It’s really rewarding, and I try to do anything and everything I can to help them.” Read full post »

A Mother’s Ambitious Goal to Raise $1 Million for Cancer Research

Christine O’Connell knows the walls of Seattle Children’s all too well.

In 2017, the O’Connell’s 3-year-old daughter Jane was diagnosed with stage IV Wilms, a pediatric kidney cancer. The cancer had spread to both of her lungs, lymph nodes and a vertebra in her spine. The months of chemotherapy, radiation and surgeries that changed their lives forever are still vivid memories.

“Radiation and chemotherapy was our only hope to save Jane’s life, but it is so damaging to young, developing bodies. She will suffer the effects of treatment for the rest of her life,” O’Connell said.

Then she learned that Seattle Children’s was pioneering a better way.

Read full post »

Six Years Later: Immunotherapy’s Tiniest Trial Participant Is Living With “So Much Joy”

Greta Oberhofer, now 7 years old, was the first patient under age 2 included in Seattle Children’s cancer immunotherapy clinical trials. Her parents once considered hospice care for their 13-month-old daughter. Now, Greta has been in remission for six years.

In the fall of 2013, Maggie and Andy Oberhofer watched their tiny, 8-month old daughter, Greta, fight for her life in the Pediatric Intensive Care Unit (PICU) at Doernbecher Children’s Hospital in Portland, Oregon.

Greta had just been through a bone marrow transplant to treat her highly aggressive leukemia. Shortly after, she took a turn for the worse and spent a perilous month in the PICU.

Greta eventually recovered from the transplant and was able to go home, but the family’s reprieve only lasted three months. In March 2014, Greta’s cancer relapsed. Her chance of survival was now 10% or less.

Her parents couldn’t imagine dragging Greta through another bone marrow transplant, so they began to consider end-of-life care for their 13-month-old daughter.

“It was gut-wrenching, knowing her odds were so low,” Maggie said. “We were preparing ourselves to say goodbye to her.”

That’s when they learned about a new option — a cancer immunotherapy trial at Seattle Children’s. Read full post »

Fatherhood, When Your Son Has Cancer

In many ways, my role as a father did not change after my 17-month old son, Isaac, was diagnosed with cancer.

Everyone faces adversity in their lives. Did I think ours would be this? Heck no. Did I want it to be this? This is the last thing I wanted. Take me before you take him, I thought.

But the severity of our situation hasn’t changed the lessons I teach my sons: In situations of extreme stress, maintain your demeanor and learn how to process and handle that stress; Be kind to people in the midst of adversity; Treat people the way you want to be treated; Be respectful.

And, never give up.

Read full post »

With Cancer on the Back Burner, Champion Junior Chef Cooks Up His Dreams

Fuller Goldsmith, 16, has always dreamed of being a top chef.

After winning the Food Network’s Chopped Jr. reality TV cooking competition, Fuller Goldsmith, 16, was well on his way to achieving his dreams of becoming a professional chef. It was a future that was soon in jeopardy when life for the aspiring chef took an uncertain, but all too familiar turn. In late 2018, Fuller learned his cancer had returned for a fourth time.

Having undergone treatment for acute lymphoblastic leukemia (ALL) since age 3, Fuller was out of standard treatment options. Their local oncologist told the Goldsmiths about the cancer immunotherapy clinical trials at Seattle Children’s. He thought the experimental chimeric antigen receptor (CAR) T-cell immunotherapy, which engineers a patient’s own immune cells to target and eliminate cancer cells, might offer the best hope for Fuller. Read full post »

From Stunning Diagnosis to Unexpected Hope: MEK Inhibitor Proves Amazing for Grace

Despite a lifetime of medical setbacks, you’ll almost always find 18-year-old Grace Carney smiling.

Grace Carney was 16 years old when she first began falling. Before long, she was falling every day. It got so bad that she had to rely on other people — family members at home and aides at school — to help her walk.

For Grace, this was the latest in a lifetime of medical setbacks, many of which stem from neurofibromatosis type one (NF1), a genetic disorder that causes tumors to grow all over the body, including under the skin and on the nerves.

To improve Grace’s ability to walk, a doctor in Spokane recommended a major orthopedic surgery. But as the Carneys prepared for that surgery, an MRI result flipped everything upside down and brought them to Seattle Children’s, where Grace received an innovative medical treatment that changed her life and could do the same for countless others with NF1. Read full post »