
Dr. Nicholas Vitanza is the program lead for Seattle Children’s Therapeutics BrainChild clinical trials
Seattle Children’s Therapeutics has launched BrainChild-04, a first-in-human phase 1 clinical trial that will be our first chimeric antigen receptor (CAR) T-cell clinical trial that targets four antigens at the same time, by delivering CAR T cells directly to the brain.
The trial is for children, teens, and young adults with diffuse intrinsic pontine glioma (DIPG), diffuse midline glioma (DMG), and other recurrent or refractory brain and spinal cord tumors.
“We believe this is the first CAR T-cell product in the world to target four antigens at the same time,” said Dr. Nicholas Vitanza, a neuro-oncologist at Seattle Children’s and the study chair for BrainChild-04.
CAR T-cell immunotherapy is an experimental treatment that stimulates the immune system to fight disease. The treatment reprograms T cells (white blood cells in the immune system that fight disease) to engage and kill cancer cells.