Nick Olson, 7, comes to Seattle Children’s for Duchenne muscular dystrophy treatment.
Tiny, sleek zebrafish could hold the key for how we treat muscular dystrophy in the future. Dr. Lisa Maves, a researcher at Seattle Children’s Research Institute, has received a grant from the National Institutes of Health to study drug combinations in zebrafish for Duchenne muscular dystrophy. It’s one of the most common forms of muscular dystrophy and affects males almost exclusively. The condition, caused by a genetic disorder of the X chromosome, gradually weakens the body’s muscles and occurs in about 1 out of every 3,500 boys.
Nick Olson is 7 years old—a redhead with a toothy smile and a stuffed animal named Puppyroni by his side. Nick has Duchenne muscular dystrophy. What does a little boy like Nick have in common with a zebrafish swimming in a tank? Genes. Zebrafish are perfect subjects for muscular dystrophy research because the same genes that caused muscular dystrophy in Nick cause it in zebrafish, too. Read full post »
Marijuana legalization has led some college-age young adults to believe marijuana is safe to use now that it’s legal in some states.
A new study from Seattle Children’s Research Institute (SCRI) shows that marijuana legalization has led some college-age young adults to believe marijuana must be safe to use now that it’s legal in some states. That’s a dangerous assumption says the study’s lead author, Dr. Megan Moreno, a Principal Investigator who studies social media and adolescent health at the Center for Child Health, Behavior and Development at SCRI.
“Marijuana interferes with brain development, and that includes young adults in college,” said Moreno. “About 5% of survey participants expressed that government legalization of marijuana must mean it is safe to use. That might seem like a small percentage. But when magnified on a larger population, it could be a substantial number of young adults who have that perception.”
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Bailey Moser, age 5
Neurosurgeons at Seattle Children’s Hospital have long suspected that epilepsy patients who have surgery earlier in life have better outcomes than those that wait. Now they have data to confirm their instincts.
In a study recently published in the Journal of Neurosurgery Pediatrics, lead author Dr. Hillary Shurtleff, neuropsychologist and investigator at Seattle Children’s Research Institute Center for Integrative Brain Research, found that early surgical treatment of focal seizures – those that affect only one area of the brain – in preschool aged children is highly beneficial. The results showed that surgery can reduce the amount of seizures and the number of medications patients are on while helping improve intelligence outcomes. Read full post »
Shannon Keating had to think about fertility preservation before she began treatment for Hodgkin lymphoma.
Family planning is not the first thing a young, newly diagnosed cancer patient might think about. But for adolescents and young adults facing cancer treatment that could leave them infertile, preserving the ability to have babies should be part of the conversation at the doctor’s office.
A new study published today in Cancer and led by Dr. Margarett Shnorhavorian, a pediatric urologist and researcher at the Seattle Children’s Research Institute Center for Clinical and Translational Research, found a need for increased awareness of fertility preservation for young cancer patients. The study was based on 459 adolescents and young adults who were diagnosed with cancer in 2007 or 2008. The patients were aged 15 to 39 years when diagnosed with germ cell tumor, non-Hodgkin lymphoma, Hodgkin lymphoma, acute lymphocytic leukemia, or sarcoma. Read full post »
In the doctor’s office, words matter. The content of a conversation between doctor, patient and parent can change the course of treatment. Shared decision-making has emerged as the dominant model in medicine for these conversations. There is even evidence it can improve patient outcomes. But should doctors reconsider its constant use? Shared decision-making and its boundaries will be the subject of a discussion led by Dr. Douglas Opel at the 11th annual Pediatric Bioethics Conference, which is being held July 24-25 at the Bell Harbor International Conference Center in Seattle.
Opel, a faculty member at the Treuman Katz Center for Pediatric Bioethics at Seattle Children’s and a general pediatrician at Seattle Children’s, sat down with On the Pulse to discuss the concept of shared decision-making. Read full post »
The attendees of the summer scholars program visiting Pike Place Market.
Most teens aren’t keen on spending summer days in camp; they’ve outgrown sleeping bags and roasting s’mores. That’s why the Social Media and Adolescent Health Research Team (SMAHRT) at Seattle Children’s Research Institute is hosting this week a summer scholars program designed to help teens create their own research projects on teen health and media.
Led by Dr. Megan Moreno, principal investigator of the SMAHRT team, the summer scholars program will ask 25 teens ages 16-18, mostly from the Kent and Highline school districts, to help design and answer their own research questions such as:
- How does Instagram affect adolescents’ well-being?
- Can you be addicted to the Internet?
- Does Facebook influence health behaviors for college students?
The students will also learn about different types of research that seek to improve child and adolescent health while experiencing different paths to a career in research or healthcare. Read full post »
Esmee (left) and Willa (right) pose for a photo.
A clinical trial was the only hope for Esmee, a little girl adopted from China. Read below about her story and the innovative research being done at Seattle Children’s Hospital and Research Institute to help those who would otherwise have no treatment option for chronic hepatitis B (HBV).
Renee Jones always wanted a little girl, so when the adoption agency called one day to tell Jones about Esmee and Willa, she was thrilled – two little girls instead of one!
She filed the paperwork for adoption and waited patiently to hear back. Read full post »
The early childhood years are crucial for learning and development which should always involve a great deal of outdoor physical activity and playtime, but new research shows that’s not always the case. Results from a two-year study published today in Pediatrics show that children in daycares and preschools were presented with only 48 minutes of opportunities for physically active play per day — significantly less than what’s recommended. The National Association for Sport and Physical Education and Let’s Move! Child Care recommend that children should receive at least 120 minutes of active play time daily, including child-led free play and teacher-led play. Read full post »
Dr. Bonnie Ramsey, director of the Center for Clinical and Translational Research at Seattle Children’s Research Institute and professor of Pediatrics at the University of Washington
Results from two phase 3 clinical trials published yesterday in the New England Journal of Medicine show that a new combination of medications can successfully treat the underlying cause of cystic fibrosis for patients age 12 and older with two copies of the F508del gene mutation – the most common form of the life-threatening, genetic disease found in over half of the cystic fibrosis (CF) population. Approximately 8,500 people in the U.S., and 22,000 people in North America, Europe and Australia, age 12 and older with cystic fibrosis carry this gene mutation.
The international trial, which studied more than 1,000 cystic fibrosis patients age 12 and older, revealed that a combination of the drugs Kalydeco (ivacaftor) and lumacaftor, an experimental drug that has not yet been approved by the Food and Drug Administration (FDA), successfully treated the defective CF protein and improved lung function. The drugs also helped patients achieve a 40 percent reduction in pulmonary exacerbations, the leading cause of death in cystic fibrosis patients. Read full post »
Dr. Raphael Bernier
Dr. Raphael Bernier, clinical director of the Autism Center and investigator in the Center for Child Health, Behavior and Development at Seattle Children’s Research Institute has continued his quest to identify genetic mutations that are linked to autism. In a new paper published in Nature Genetics, Bernier and his collaborators at the University of Washington discovered evidence that some children with autism were more likely to have inherited gene mutations most often occurring from mothers to sons.
On the Pulse sat down with Bernier to learn more about these exciting findings. Read full post »